There are systems of compounds that exhibit [2+2] photodimerization when exposed to UV light when co-crystallized with an apposite template molecule. Co-crystals, crystalline structures made up of two or more compounds in a specific stoichiometric ratio, help position molecules in the specific orientation necessary for the [2+2] photodimerization to occur, which can be detected by analysis via 1H NMR spectroscopy.
4-[(E)-2-(Pyridin-4-yl)vinyl]phenol (“OED”), a dye-derivative, exhibited potential for photodimerization in a co-crystalline state. Analysis of co-crystal synthesis attempts via Raman spectroscopy showed that unaltered OED is unable to form cocrystals with the customary templating molecules, invoking the unprecedented synthesis confirmed by 1H NMR spectroscopy of an OED-derived compound, bis-OED phthalate, for further investigation as a photoreactive compound.
Justin Pruitt, ’16
Sponsor: Charles Liber